Kai Zacharowski Selected Research

Septic Shock (Toxic Shock Syndrome)

6/2021	Efficacy and safety of early target-controlled plasma volume replacement with a balanced gelatine solution versus a balanced electrolyte solution in patients with severe sepsis/septic shock: study protocol, design, and rationale of a prospective, randomized, controlled, double-blind, multicentric, international clinical trial : GENIUS-Gelatine use in ICU and sepsis.
3/2019	Personalized medicine with IgGAM compared with standard of care for treatment of peritonitis after infectious source control (the PEPPER trial): study protocol for a randomized controlled trial.
5/2015	Should we restrict erythrocyte transfusion in early goal directed protocols?
1/2009	Toll-like receptor pathway signaling is differently regulated in neutrophils and peripheral mononuclear cells of patients with sepsis, severe sepsis, and septic shock.

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Kai Zacharowski Research Topics

Disease

35	Inflammation (Inflammations) 02/2024 - 07/2007
35	Sepsis (Septicemia) 01/2023 - 11/2004
29	Anemia 02/2024 - 04/2011
26	Hemorrhage 02/2024 - 07/2006
25	COVID-19 02/2024 - 01/2020
21	Ischemia 04/2021 - 10/2002
20	Critical Illness (Critically Ill) 04/2024 - 09/2012
19	Reperfusion Injury 01/2023 - 10/2002
13	Acute Kidney Injury (Acute Renal Failure) 01/2023 - 02/2013
13	Infections 01/2022 - 01/2009
12	Myocardial Infarction 01/2023 - 06/2006
11	Neoplasms (Cancer) 10/2023 - 09/2007
10	Wounds and Injuries (Trauma) 01/2023 - 01/2009
10	Myocardial Ischemia (Ischemic Heart Diseases) 10/2019 - 06/2007
10	Infarction (Infarctions) 01/2013 - 03/2005
8	Pneumonia (Pneumonitis) 01/2023 - 10/2007
8	Shock 01/2021 - 12/2007
7	Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome) 01/2022 - 12/2007
7	Iron Deficiencies 01/2022 - 01/2020
6	Hypoxia (Hypoxemia) 01/2017 - 01/2012
5	Disease Progression 02/2024 - 01/2010
5	Renal Insufficiency (Renal Failure) 06/2022 - 07/2013
5	Iron-Deficiency Anemia (Anemia, Iron Deficiency) 08/2021 - 06/2017
5	Edema (Dropsy) 05/2014 - 01/2009
4	Heart Arrest (Cardiac Arrest) 01/2023 - 01/2012
4	Body Weight (Weight, Body) 06/2022 - 02/2009
4	Stroke (Strokes) 01/2022 - 10/2015
4	Septic Shock (Toxic Shock Syndrome) 06/2021 - 01/2009
4	Thrombosis (Thrombus) 12/2020 - 08/2012
4	Necrosis 01/2013 - 04/2008
4	Bacterial Infections (Bacterial Infection) 01/2011 - 11/2004
3	Carcinoma (Carcinomatosis) 08/2022 - 09/2007
3	Respiratory Insufficiency (Respiratory Failure) 09/2021 - 04/2015
3	Delirium 01/2020 - 10/2018
3	Acute Lung Injury 09/2017 - 02/2009
2	Placenta Accreta 02/2024 - 01/2024
2	Multiple Organ Failure (MODS) 10/2023 - 03/2019
2	Postpartum Hemorrhage 09/2023 - 04/2019
2	Pain (Aches) 09/2023 - 03/2022
2	Thrombocytopenia (Thrombopenia) 09/2023 - 01/2016
2	Ischemic Stroke 01/2023 - 11/2019
2	Communicable Diseases (Infectious Diseases) 12/2022 - 01/2022
2	Rare Diseases (Rare Disease) 07/2022 - 01/2021

Drug/Important Bio-Agent (IBA)

18	phytobacteriomycin (PBM)IBA 09/2023 - 04/2014
18	Toll-Like Receptors (Toll-Like Receptor)IBA 11/2015 - 11/2004
13	FibrinIBA 01/2021 - 03/2005
12	Peptides (Polypeptides)IBA 10/2023 - 03/2005
11	CytokinesIBA 10/2023 - 06/2007
10	Biomarkers (Surrogate Marker)IBA 10/2023 - 07/2011
9	IronIBA 04/2023 - 06/2017
8	Hemoglobins (Hemoglobin)IBA 12/2023 - 04/2012
8	Toll-Like Receptor 2IBA 10/2019 - 03/2010
7	Proteins (Proteins, Gene)FDA Link 02/2024 - 01/2009
7	Interleukin-6 (Interleukin 6)IBA 10/2023 - 06/2007
7	Hemostatics (Antihemorrhagics)IBA 09/2021 - 09/2012
7	LigandsIBA 01/2021 - 04/2006
6	Troponin T (Troponin T1)IBA 04/2018 - 03/2010
5	Oxygen (Dioxygen)IBA 01/2021 - 02/2009
5	LipopolysaccharidesIBA 01/2013 - 03/2006
4	Tranexamic Acid (AMCA)FDA Link 12/2022 - 06/2017
4	SolutionsIBA 06/2022 - 01/2013
4	Starch (Cornstarch)IBA 06/2022 - 04/2011
4	Immunoglobulins (Immunoglobulin)IBA 01/2022 - 01/2016
4	Anti-Bacterial Agents (Antibiotics)IBA 11/2021 - 04/2015
4	Messenger RNA (mRNA)IBA 01/2016 - 12/2010
4	Colloids (Colloid)IBA 09/2014 - 04/2011
4	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 05/2014 - 01/2012
4	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 07/2013 - 06/2007
3	ChemokinesIBA 02/2024 - 03/2010
3	ElectrolytesIBA 06/2022 - 01/2019
3	InterleukinsIBA 09/2021 - 04/2008
3	salicylhydroxamic acid (SHAM)IBA 04/2018 - 10/2015
3	Blood Coagulation Factors (Coagulation Factor)IBA 06/2017 - 05/2013
3	Fibrinogen (Factor I)FDA Link 06/2017 - 03/2005
3	EndotoxinsIBA 01/2016 - 05/2013
3	CPG-oligonucleotideIBA 10/2013 - 10/2007
3	GlucocorticoidsIBA 09/2013 - 03/2009
3	lipoteichoic acidIBA 11/2008 - 10/2002
3	Toll-Like Receptor 9IBA 04/2008 - 07/2007
2	LipidsIBA 02/2024 - 01/2018
2	EnzymesIBA 12/2022 - 10/2018
2	Heparin (Liquaemin)FDA LinkGeneric 12/2022 - 09/2012
2	Hypnotics and Sedatives (Sedatives)IBA 01/2022 - 01/2021
2	AntioxidantsIBA 01/2022 - 01/2018

Therapy/Procedure

44	Therapeutics 04/2024 - 07/2008
16	Critical Care (Surgical Intensive Care) 02/2024 - 09/2014
11	Erythrocyte Transfusion 01/2024 - 04/2016
10	Length of Stay 09/2023 - 10/2015
9	Extracorporeal Membrane Oxygenation 04/2024 - 03/2012
7	Blood Transfusion (Blood Transfusions) 02/2024 - 04/2017
7	Artificial Respiration (Mechanical Ventilation) 01/2024 - 04/2015
7	Ligation 01/2017 - 10/2010
6	Resuscitation 09/2021 - 02/2009
4	Bloodless Medical and Surgical Procedures 02/2024 - 03/2019
4	Renal Replacement Therapy (Therapies, Renal Replacement) 01/2023 - 07/2013
4	Punctures 01/2017 - 07/2011
3	Anesthesia 12/2020 - 01/2012
3	Cardiopulmonary Bypass (Heart-Lung Bypass) 04/2018 - 01/2013
3	Lung Transplantation 05/2014 - 01/2012
2	Catheters 09/2023 - 01/2011